Tumor–Stroma Interactions Drive 3D Growth and Self-Organization in PDAC Spheroids: A Quantitative Study in Microfluidic Models

Authors

  • Soraya Hernández-Hatibi I3A
  • Carlos Borau
  • Neus Martínez-Bosch
  • Pilar Navarro
  • José Manuel García-Aznar
  • Pedro Enrique Guerreo

DOI:

https://doi.org/10.26754/jji-i3a.202511975

Abstract

We present a microfluidic-based 3D model of pancretic cancer that reveals how tumor–stroma interactions and matrix mechanics govern spheroid self-organization. Using quantitative imaging, we uncover cell type–specific growth patterns and stromal responses. This platform advances in vitro modeling of pancretaic cancer heterogeneity and reveals biomechanical drivers of tumor architecture.

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Published

2025-07-28

Issue

Vol. 13 (2025): Actas de la XIV Jornada de Jóvenes Investigadores e Investigadoras del I3A - 25 de junio de 2025

Section

Artículos (Ingeniería Biomédica)

License

Copyright (c) 2025 Soraya Hernandez, Carlos Borau , Neus Martínez Bosch , Pilar Navarro, José Manuel García Aznar , Pedro Enrique Guerrero

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Hernández Hatibi , S. ., Borau , C., Martínez Bosch , N., Navarro, P. ., García Aznar , J. M. ., & Guerrero , P. E. (2025). Tumor–Stroma Interactions Drive 3D Growth and Self-Organization in PDAC Spheroids: A Quantitative Study in Microfluidic Models. Jornada De Jóvenes Investigadores Del I3A, 13. https://doi.org/10.26754/jji-i3a.202511975